Yijin Wang
   Basic researcher
   University
Fields of Expertise:
-
SUBJECTS OF INTEREST

POSITIONS
Associated professor

Southern university of science and technology





BIOGRAPHY

Understanding pathogenesis of hepatitis E on the basis of HEV viral infection courses, viral-host interaction, mechanisms of HEV activating and escaping innate immunity, and the antagonism to IFN therapy. Development of potential economical, less side-effect anti-HEV strategy. Resolving the clinica... Read more
Understanding pathogenesis of hepatitis E on the basis of HEV viral infection courses, viral-host interaction, mechanisms of HEV activating and escaping innate immunity, and the antagonism to IFN therapy. Development of potential economical, less side-effect anti-HEV strategy. Resolving the clinical practical challenges of hepatitis E, including diagnosis, diseases courses in distinct populations, prognosis and extra-hepatic manifestation. Elucidating novel mechanism of innate immune response，particularly based on nucleotide synthesis inhibition, mitochondrial function. Non-invasive diagnosis for severe non-infectious liver diseases, such as NAFLD, ICC

SCIENTIFIC TRAININGS & EDUCATION

POSITIONS
  • -
Associated professor

Southern university of science and technology

KEY PUBLICATIONS | ALL PUBLICATIONS

Hepatitis E virus infection activates NOD-like receptor family pyrin domain-containing 3 inflammasome antagonizing interferon response but therapeutically targetable

Yang Li , Peifa Yu , Amy L Kessler , Jingyi Shu , Xiaoyan Liu , Zhaochao Liang , Jiaye Liu , Yunlong Li , Pengfei Li , Ling Wang , Yining Wang , Zhongren Ma , Aixia Liu , Ling Wang , Marco J Bruno , Robert A de Man , Maikel P Peppelenbosch , Sonja I Buschow , Lin Wang , Yijin Wang , Qiuwei Pan

Publication: Hepatology/2022/75(1)/196-212


Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids

Pengfei Li , Yunlong Li , Yijin Wang , Jiaye Liu , Marla Lavrijsen , Yang Li , Ruyi Zhang , Monique M A Verstegen , Yining Wang , Tian-Cheng Li , Zhongren Ma , Denis E Kainov , Marco J Bruno , Robert A de Man , Luc J W van der Laan , Maikel P Peppelenbosch , Qiuwei Pan

Publication: Science Advances/2022/8(3)/eabj5908


Incidence, predictors and prognosis of genotype 4 hepatitis E related liver failure: A tertiary nested case-control study

Yijin Wang , Hongyang Liu , Shuhong Liu , Changshuang Yang , Yiyun Jiang , Shan Wang , Aixia Liu , Maikel P Peppelenbosch , Nassim Kamar , Qiuwei Pan , Jingmin Zhao

Publication: Liver International/2019/39(12)/2291-2300


Chronic Hepatitis E in a Renal Transplant Recipient: The First Report of Genotype 4 Hepatitis E Virus Caused Chronic Infection in Organ Recipient

Yijin Wang , Guofeng Chen , Qiuwei Pan , Jingmin Zhao

Publication: Gastroenterology/2018/154(4)/1199-1201


Hepatitis E virus infection in acute non-traumatic neuropathy: A large prospective case-control study in China

Yijin Wang , Shan Wang , Jian Wu , Yiyun Jiang , Haiying Zhang , Shujuan Li , Hongyang Liu , Changshuang Yang , Haijun Tang , Naizhou Guo , Maikel P Peppelenbosch , Lai Wei , Qiuwei Pan , Jingmin Zhao

Publication: EBioMedicine/2018/36/122-130


The RNA Genome of Hepatitis E Virus Robustly Triggers an Antiviral Interferon Response

Wenshi Wang , Yijin Wang , Changbo Qu , Shan Wang , Jianhua Zhou , Wanlu Cao , Lei Xu , Buyun Ma , Mohamad S Hakim , Yuebang Yin , Tiancheng Li , Maikel P Peppelenbosch , Jingmin Zhao , Qiuwei Pan

Publication: Hepatology/2018/67(6)/2096-2112


RIG-I is a key antiviral interferon-stimulated gene against hepatitis E virus regardless of interferon production

Lei Xu , Wenshi Wang , Yunlong Li , Xinying Zhou , Yuebang Yin , Yijin Wang , Robert A de Man , Luc J W van der Laan , Fen Huang , Nassim Kamar , Maikel P Peppelenbosch , Qiuwei Pan

Publication: Hepatology/2017/65(6)/1823-1839


Hepatitis E Virus Infects Neurons and Brains

Xinying Zhou , Fen Huang , Lei Xu , Zhanmin Lin , Femke M S de Vrij , Ane C Ayo-Martin , Mark van der Kroeg , Manzhi Zhao , Yuebang Yin , Wenshi Wang , Wanlu Cao , Yijin Wang , Steven A Kushner , Jean Marie Peron , Laurent Alric , Robert A de Man , Bart C Jacobs , Jeroen J van Eijk , Eleonora M A Aronica , Dave Sprengers , Herold J Metselaar , Chris I de Zeeuw , Harry R Dalton , Nassim Kamar , Maikel P Peppelenbosch , Qiuwei Pan

Publication: The Journal of Infectious Diseases/2017/215(8)/1197-1206


Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication

Wenshi Wang , Yijin Wang , Yannick Debing , Xinying Zhou , Yuebang Yin , Lei Xu , Elena Herrera Carrillo , Johannes H Brandsma , Raymond A Poot , Ben Berkhout , Johan Neyts , Maikel P Peppelenbosch , Qiuwei Pan

Publication: Antiviral Research/2017/140/1-12


Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication

Xinying Zhou , Lei Xu , Yijin Wang , Wenshi Wang , Dave Sprengers , Herold J Metselaar , Maikel P Peppelenbosch , Qiuwei Pan

Publication: Antiviral Research/2015/124/11-19


Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus

Yijin Wang , Xinying Zhou , Yannick Debing , Kan Chen , Luc J.W. Van Der Laan , Johan Neyts , Harry L.A. Janssen , Herold J.Metselaar , Maikel P.Peppelenbosch , Qiuwei Pan

Publication: Gastroenterology/2014/146(7)/1775-1783


Rapamycin and everolimus facilitate hepatitis E virus replication: revealing a basal defense mechanism of PI3K-PKB-mTOR pathway

Xinying Zhou , Yijin Wang , Herold J Metselaar , Harry L A Janssen , Maikel P Peppelenbosch , Qiuwei Pan

Publication: Journal of Hepatology/2014/61(4)/746-754


INTERESTS