Qiuwei Abdullah Pan
   Translational researcher
   University Hospital
   Thought Leader
   Super Expert
Fields of Expertise:
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SUBJECTS OF INTEREST

POSITIONS
  • 2012 - Present
Group Leader/Associate Professor

Department of Gastroenterology and Hepatology; Erasmus MC Rotterdam





BIOGRAPHY

Shortly after dissertation of PhD thesis in 2012, Dr. Pan started to establish his own research group at Erasmus MC. He initiated translational research of hepatitis E virus (HEV), which was a neglected pathogen at that time. So far, he has contributed over 60 publications to this topic alone with m... Read more
Shortly after dissertation of PhD thesis in 2012, Dr. Pan started to establish his own research group at Erasmus MC. He initiated translational research of hepatitis E virus (HEV), which was a neglected pathogen at that time. So far, he has contributed over 60 publications to this topic alone with major contributions to understanding virus-host interactions and developing antiviral therapy. His team has pioneered the applications of organoids technology for virus research, in particular for rotavirus, coronavirus, mpox virus and HEV. Dr. Pan has also developed research lines in studying fatty liver disease and liver cancer. In response to COVID-19 and mpox outbreak, his team immediately initiated coronavirus and mpox virus research taking multidimensional approaches. His research has been supported by several prestigious (personal) grants. His research portfolio has led to important societal impact and over 250 scientific publications as well as many prestigious awards, including the EASL Emerging Leader Award (2021) by the European Association for the Study of the Liver for his outstanding contribution to the HEV field. Currently, Dr. Pan is dedicating to engage multi-stakeholders to advance hepatitis E research, education, public health and patient care, aiming at benefiting both the infected patients and the society at large.

SCIENTIFIC TRAININGS & EDUCATION

  • 2007-04-01 - 2012-02-22

    PhD
    Ersamus University Rotterdam, The Netherlands

  • 2004-09-01 - 2007-03-31

    Master
    Zhejiang Sci-Tech University, Hangzhou, China.

  • 2000-09-01 - 2004-05-28

    Bachelor
    Northwest Minzu University, Lanzhou, China.

POSITIONS
  • 2012 - Present
Group Leader/Associate Professor

Department of Gastroenterology and Hepatology; Erasmus MC Rotterdam

KEY PUBLICATIONS | ALL PUBLICATIONS

Hepatitis E virus infection remodels the mature tRNAome in macrophages to orchestrate NLRP3 inflammasome response

Li Y, Zhang R, Wang Y, Li P, Li Y, Janssen HLA, de Man RA, Peppelenbosch MP, Ou X, Pan Q.

Publication: Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304445120.


Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids

Li P, Li Y, Wang Y, Liu J, Lavrijsen M, Li Y, Zhang R, Verstegen MMA, Wang Y, Li TC, Ma Z, Kainov DE, Bruno MJ, de Man RA, van der Laan LJW, Peppelenbosch MP, Pan Q.

Publication: Science Advances. 2022 Jan 21;8(3):eabj5908.


Hepatitis E virus infection activates NOD-like receptor family pyrin domain-containing 3 inflammasome antagonizing interferon response but therapeutically targetable

Li Y, Yu P, Kessler AL, Shu J, Liu X, Liang Z, Liu J, Li Y, Li P, Wang L, Wang Y, Ma Z, Liu A, Wang L, Bruno MJ, de Man RA, Peppelenbosch MP, Buschow SI, Wang L, Wang Y, Pan Q.

Publication: Hepatology . 2022 Jan;75(1):196-212.


Mpox virus infection and drug treatment modelled in human skin organoids

Li P, Pachis ST, Xu G, Schraauwen R, Incitti R, de Vries AC, Bruno MJ, Peppelenbosch MP, Alam I, Raymond K, Pan Q.

Publication: Nature Microbiology. 2023 Oct 12.


Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment

Li P, Du Z, Lamers MM, Incitti R, Tejeda-Mora H, Li S, Schraauwen R, van den Bosch TPP, de Vries AC, Alam IS, Haagmans BL, Hoogduijn MJ, Pan Q.

Publication: Cell Discovery. 2023 Apr 3;9(1):34.


Preventing drug resistance: combination treatment for mpox

Pengfei Li, Jaffar A. Al-Tawfiq, Ziad A. Memish, Qiuwei Pan.

Publication: Lancet. 2023, Nov 11;402(10414):1750-1751.


Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response

Wang Y, Li P, Xu L, de Vries AC, Rottier RJ, Wang W, Crombag MBS, Peppelenbosch MP, Kainov DE, Pan Q.

Publication: iScience. 2023 Aug 16;26(9):107631.


SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination

Li P, Wang Y, Lavrijsen M, Lamers MM, de Vries AC, Rottier RJ, Bruno MJ, Peppelenbosch MP, Haagmans BL, Pan Q.

Publication: Cell Research. 2022 Mar;32(3):322-324.


Potential association between COVID-19 mortality and health-care resource availability

Ji Y, Ma Z, Peppelenbosch MP, Pan Q.

Publication: Lancet Global Health. 2020 Apr;8(4):e480.


Monitoring and managing SARS-CoV-2 evolution in immunocompromised populations

Li P, de Vries AC, Kamar N, Peppelenbosch MP, Pan Q.

Publication: Lancet Microbe . 2022 May;3(5):e325-e326.


LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Cao W, Li M, Liu J, Zhang S, Noordam L, Verstegen MMA, Wang L, Ma B, Li S, Wang W, Bolkestein M, Doukas M, Chen K, Ma Z, Bruno M, Sprengers D, Kwekkeboom J, van der Laan LJW, Smits R, Peppelenbosch MP, Pan Q.

Publication: Nature Communications. 2020 Apr 23;11(1):1961.


My latest published articles
INTERESTS
ACHIEVEMENTS
EASL Emerging Leader 2021

Award

Vidi laureate 2019

NWO Talent Program

Dutch Cancer Society Young Investigator Fellowship 2017

Career Development Grant

Daniel den Hoed Foundation Centennial Fellowship 2014

Career Development Grant

Dutch Digestive Disease Foundation Fellowship 2013

Career Development Grant

EASL Sheila Sherlock Fellowship 2013

International training

ILTS International Travel Scholar Grant 2013

International training

Veni laureate 2012

NWO Talent Program

ILTS Rising Star 2009

Award