Lin Wang
   Translational researcher
   University
Fields of Expertise:
-
POSITIONS
Assistant Professor (PI)

Peking University Health Science Center





BIOGRAPHY

A desirable small animal model is urgently needed for HEV study. Our lab mainly focuses on developing a small animal model that can recapitulate key clinical features of human HEV infections and investigate the potential host tropism determinants.

SCIENTIFIC TRAININGS & EDUCATION

POSITIONS
  • -
Assistant Professor (PI)

Peking University Health Science Center

KEY PUBLICATIONS | ALL PUBLICATIONS

An Immunocompetent Mongolian Gerbil Model for Hepatitis E Virus Genotype 1 Infection

Liu Tianxu, He Q, Yang X, Li Y, Yuan D, Lu Q, Tang T, Guan G, Zheng L, Zhang H, Xia C, Yin X, Wei G, Chen X, Lu F, Wang Lin*

Publication: Gastroenterology, 2024;167(4):750-763.e10


Optimization of immunosuppression strategies for the establishment of chronic hepatitis E virus infection in rabbits

He Q, Liu Tianxu, Yang X, Yuan D, Lu Q, Li Y, Zhang H, Liu X, Xia C, Sridhar S, Tian L, Liu X, Meng L, Ning J, Lu F, Wang L, Yin X, Wang Lin*

Publication: Journal of Virology, 2024;98(7):e0084624


Immunocompromised rabbit model of chronic HEV reveals liver fibrosis and distinct efficacy of different vaccination strategies

He Q, Zhang F, Shu J, Li S, Liang Z, Du M, Liu X, Liu Tianxu, Li M, Yin X, Pan Q, Lu F*, Wang L*, Wang Lin*

Publication: Hepatology. 2022;76(3):788-802


Urine is a viral antigen reservoir in hepatitis E virus infection

Ying D#, He Q#, Tian W#, Chen Y#, Zhang X, Wang S, Liu C, Chen Z, Liu Y, Fu L, Yan L, Wang L, Tang Z*, Wang Lin*, Zheng Z*, Xia N*

Publication: Hepatology. 2023;77(5):1722-1734


Hepatitis E virus infection activates NOD-like receptor family pyrin domain-containing 3 inflammasome antagonizing interferon response but therapeutically targetable

Li Y, Yu P, Kessler AL, Shu J, Liu X, Liang Z, Liu J, Li Y, Li P, Wang L, Wang Y, Ma Z, Liu A, Wang L, Bruno MJ, de Man RA, Peppelenbosch MP, Buschow SI, Wang Lin*, Wang Y*, Pan Q*

Publication: Hepatology. 2022;75(1):196-212


Hepatitis E virus infects human testicular tissue and Sertoli cells

Liu Tianxu#, Cao Y#, Weng J, Gao S, Jin Z, Zhang Y, Yang Y, Zhang H, Xia C, Yin X, Luo Y, He Q, Jiang H*, Wang Lin*, Zhang Z*

Publication: Emerging Microbes&Infection. 2024;13(1):2332657


Infectivity and pathogenicity of different hepatitis E virus genotypes/subtypes in rabbit model

Li S#, He Q#, Yan L, Li M, Liang Z, Shu J, Zhang F, Wang L*, Wang Lin*

Publication: Emerging Microbes&Infection. 2020;9(1):2697-2705


High dose sofosbuvir and sofosbuvir-plus-ribavirin therapy inhibit Hepatitis E Virus (HEV) replication in a rabbit model for acute HEV infection

Liang Z#, Shu J#, He Q, Zhang F, Dai L, Wang L*, Lu F*, Wang Lin*

Publication: Antiviral Research. 2022;199:105274


Transmission of a Novel Genotype of Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques

Wang Lin, Teng JLL, Lau SKP, Sridhar S, Fu H, Gong W, Li M, Xu Q, He Y, Zhuang H, Woo PCY*, Wang L*

Publication: Journal of Virology. 2019;93(7):e02014-18


Absence of hepatitis E virus RNA in semen samples of infertile male in China

Wang Lin#, Zhang Z#, Shu J#, Zhang H, Yang Y, Liang Z, He Q, Huang W, Wang Y, Zhuang H, Jiang H*, Wang L*

Publication: Gut. 2020;69(7):1363-1364


Association of hepatitis E virus infection and myasthenia gravis: A pilot study

Wang Lin, Gao F, Lin G, Yuan Y, Huang Y, Hao H*, Zhuang H, Wang Ling*

Publication: Journal of Hepatology. 2018;68(6):1318-1320


Experimental infection of rabbits with genotype 3 hepatitis E virus produced both chronicity and kidney injury

Wang Lin, Xia J, Wang L*, Wang Y*

Publication: Gut. 2017;66(3):561-562